ABSTRACT
Objective@#To explore the impact of procedural behavior management on children with dental fear (DF) using the interactive mode of coparticipative doctor-patient interactions.@*Methods@#Ninety-eight children with dental fear and aged 3-6 years were randomly divided into an observation group and a control group. Dental treatment was performed on the observation group under the coparticipation model, while the control group adopted the traditional tell-show-do (TSD) operation. The entire process of diagnosing and treating each child was recorded, and the degree of dental fear was assessed using a behavioral grading method as the standard.@*Results@#The degrees of fear in the children in the observation group and the control group were 3.571 ± 0.913 and 3.857 ± 1.000. The two groups showed no significant difference in the degree of fear (t=1.477, P > 0.05). During the treatment, the fear scores of the children in the observation group and the control group were 1.428 ± 1.061 and 3.286 ± 0.707. The two groups showed statistically significant differences in fear scores (t=10.198, P < 0.001).@*Conclusion @#In the coparticipative model, the fear level of DF children was significantly reduced by process-based behavior management, which helped to improve the dental fear of the children.
ABSTRACT
Background & objectives: The effectiveness of interleukin-2 (IL-2) and induced killer cells for non-small cell lung cancer (NSCLC) is controversial. This study evaluates the efficacy and safety of interleukin-2 and induced killer cells on NSCLC, so as to provide references for further clinical practice and research. Methods: Relevant randomized controlled trials (RCTs) were searched in Cochrane library (Issue 2, 2013), Web of Science (1980-March 2013), PubMed (1966-March 2013), China Knowledge Resource Integrated database (CNKI) (1994-March 2013), China Biology Medicine database (CBM) (1978-March 2013), VIP (1989-March 2013), and Wan Fang databases (1997-March 2013). There were no language restrictions. After independent quality assessment and data extraction by two authors, meta-analysis was conducted by RevMan 5.1 software. Results: Ten RCTs were included. Odds ratio (OR), 95% confidence intervals (CI), P value expressed as test group (interleukin-2 or induced killer cells combined chemotherapy) versus control group (chemotherapy alone), was 2.02 (1.24, 3.29; P=0.004) for disease control rate. Hazard ratios (HR) (95% CI; P value), expressed as test group (interleukin-2 or induced killer cells) versus control group, were 0.60 (0.46, 0.79; P=0.0003) for overall survival of postoperative treatment, and 0.77 (0.60, 0.99; P =0.04) for overall survival of combination with chemotherapy. Mean differences (MD) (95% CI; P value), expressed as test group (interleukin-2 or induced killer cells) versus control group (after treatment), were 11.32 (6.32, 16.33; P=0.00001) for NK cells, 11.79 (2.71, 20.86; P=0.01) for CD3+ cells, 14.63 (2.62, 26.64; P=0.02) for CD4+ cells, and -4.49 (-7.80, 1.18; P=0.008) for CD8+ cells. Interpretation & conclusions: The meta-analysis showed that IL-2 or induced killer cells combination therapy was efficacious in treating NSCLC and improved overall survival. Further analysis of trials having adequate information and data need to be done to confirm these findings.